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World Cancer day (Cancer Invasion)

We had posted on the importance of TCM to cancer where we talked about some mushroom like Ganoderma Lucidum and all that. But today being world cancer day, we just feel like saying one or two things about cancer and we picked the migrating nature of Cancer.
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other part of the body. Cancer is mostly caused by life-style. 22% of people with cancer use tobacco that is why the cigarette has it written boldly on the pack that smokers are liable to die young. I something hear people call cigarette cancer stick. 10 percent is caused by obesity. We try to give our readers with sweet tooth a substitute food for there addiction with lower calories in our calorie balance. Poor nutrition, alcoholic intake and one which is worthy of note is genetic mutation. We expose ourselves to electromagnetic material like our mobile phones which is a transceiver. If we have any reason to fear for people living close to a telecommunication mast, then fear for yourself because the same electromagnetic energy on the mast is same with what our mobile phone carries. So apart from inheriting cancer via hereditary electromagnetism could be a threat but not to scare you, it's just an hypothesis.

Just as we said earlier, our focus is seeing how  TCM could be an inhibitor to stop the migrating characteristic of cancer. From studies, they are two main patterns of cancer invasion: collective cell migration, and individual cell migration by which tumor cells overcome barriers of the extracellular matrix and spread into surrounding tissues. I really don’t want to go into the science behind the migration but want to talk about Ginseng RH2 and it’s tendency to curb the migration of cancer or even prevent one from cancer.

Many studies have demonstrated that most of the pharmacological and therapeutic actions of ginseng in the treatment of cancers, diabetes and cardiovascular disorders, or in modulation of central nervous system and endocrine functions, are attributed to ginsenosides. This review focused on two commercially available ginsenosides - Rg3 (Rg3 Shenyi Jiaonang from China) and it metabolites Rh2 (GOOD LIFE ginsenoside Rh2 capsule from Taiwan), and their effects on the inhibition and prevention of cancers.

Existing evidence shows that prolonged administration of red ginseng extracts significantly reduces the incidence of cancer. Animal studies also demonstrate that Rg3 can lower the lung cancer risk, while Rh2 exhibits a tendency of similar benefit. Biological investigations indicate that Rg3 and Rh2 inhibit tumor growth in vitro and in vivo through induction of cell death, inhibition of cell proliferation, invasion and metastasis. We also observed the anti-cancer properties of Rg3 which are related to anti-angiogenesis. Rg3 abolished in vitro tubulogenesis of endothelial cells, in vivo neo-vessels formation in the Matrigel plug model and ex vivo endothelial sprouting of rat aortic fragments. Moreover, DNA microarray analysis further elucidates that Rg3 can modulate the expression of some genes which are related to chromatin remodeling, cytoskeleton, apoptosis, protein folding and tumor suppression. On the other hand, multi-drug resistance is another major concern in cancer chemotherapy. Rg3 can compete with anticancer drugs for binding to Pglycoprotein thereby reducing the drug efflux.

As well as today is set aside to help watch our lifestyle to prevent cancer, we should also praise TCM for the secret of Ginseng. When we remember world cancer day, please remember this old TCM ginseng. In TCM words, it's ginseng day.


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