Introduction Mpox, formerly known as Monkeypox, is a zoonotic viral disease that has recently garnered global attention due to its outbreaks beyond the endemic regions in Central and West Africa. The re-emergence and spread of Mpox across African nations, including Nigeria, has raised concerns regarding public health infrastructure, disease surveillance, and mitigation strategies. The Impact of Mpox in Africa Mpox has historically been confined to the tropical rainforests of Central and West Africa. However, with recent outbreaks in urban areas and even international spread, the disease has demonstrated its potential to cause significant health, economic, and social disruptions. In Africa, the impact has been particularly severe due to limited healthcare resources, challenges in disease detection, and a lack of widespread vaccination programs. The economic implications are also significant, as outbreaks can disrupt trade, tourism, and agricultural activities. Furthermore, the stigma as...